The topic of this article is Rheumatoid Arthritis. What is this disease, how to identify it at the initial stage and how to maintain the health of our joints.
Check yourself - if in the morning you experience problems moving the joints of your hands, pain, inability to straighten your fingers, then most likely you suffer from rheumatoid arthritis.
In people suffering from rheumatoid polyarthritis, the small joints of the hands are primarily affected and problems are especially pronounced in the places where the fingers are attached to the following bones and changes in the wrist joints are very noticeable.
Why and how does this happen?
If we look at healthy joints, we will see the following: the inner surface of the joints consists of cartilage, the cartilage is smooth and the joints themselves are covered with capsules and they are not inflamed.
The immune system is designed in such a way that there is always a small amount of autoantibodies in our body; they serve to ensure that our immune system understands where foreign antibodies and tissues are and where our own are.
In pathology (rheumatoid arthritis), the antigenic structure of cartilage is partly similar to the antigenic structure of viruses, bacteria, streptococci, which inevitably enter the body and the body, killing these pathogens, begins to react to its own tissues as if they were foreign and produce chemicals that begin to destroy our own cartilage tissue , the layer of hyaline cartilage between the contacting surfaces of the bones is disrupted, as a result of which the person begins to feel pain in the joint.
The body seems to have gone crazy, it has ceased to distinguish between what is ours and what is someone else’s, and not only our joints suffer, but the heart, lungs, kidneys, and eyes are also affected.
Symptoms of rheumatoid arthritis that should make a person go to the doctor
There are signs that can help identify problems with joint health in the early stages.
When you get your blood tested and find out that your erythrocyte sedimentation rate has increased (in numbers - 50.60), this means that you may be developing rheumatoid arthritis.
In addition, if there is an increased level of C-reactive protein in the blood, this means that strong inflammatory processes have begun in your body.
X-ray research methods, which at very early stages can tell that this is the debut of rheumatoid arthritis.
How to treat rheumatoid arthritis
If earlier there was nothing to be done, it was necessary to extinguish inflammation and for this they used hormones and cytostatics, substances that killed all cells indiscriminately, now things are much better. Now a new class of drugs has emerged, these are drugs containing monoclonal antibodies that affect “frenzied” immune cells.
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I want people who have joint pain to hear me: small joints, not only small joints, but also those who have been diagnosed with Rheumatoid Arthritis .
An absolutely revolutionary change in the treatment of this disease. I would like to introduce you to the guest of our program today, this is doctor, professor of medical sciences, deputy director of the Institute of Rheumatology Dmitry Evgenievich Koroteev.
Before we start talking about a new treatment method, I want to show you the hands of our patient today, this is Lyudmila. These are hands that have simply been damaged by rheumatoid arthritis. This is what patients with rheumatoid arthritis look like when deformities have already occurred.
This is how people’s hands become crippled by rheumatoid arthritis after twenty years of unsuccessful treatment. But much more than these deformations, people are tormented by pain, inhuman terrible pain. Having receded for a while, they appear again and again; it is the cartilage inside each joint that is systematically destroyed.
For many years, the cause of this disease remained a mystery. It was not clear why no medications help with treatment? It turned out that the nature of inflammation in such arthritis is completely special.
The main role in its development is played by the unusual molecules “ Interleukin 6 ”. It is this interleukin that destroys cartilage and prevents inflammation from stopping, and it is this unusual molecule that is associated with the hellish pain that regularly torments patients and severe joint deformities that arise gradually and remain for life.
I want to say that Dmitry Evgenievich heads the department of early arthritis at the Institute of Rheumatology.
This is certainly not early but late arthritis. Yes?
And I want to say, our Lyudmila (approx. - Patient) was among those patients who were treated with a new medicine. This medicine is called Actemra.
Lyudmila, please tell me what bothered you the most before treatment and what you managed to get rid of?
You know, I managed to get rid of pain, severe pain. I have now started taking different medications less, I practically don’t take them – this is also not unimportant.
How often is this drug taken?
Is this injection administered once a month?
Yes, intravenous administration.
And how does it work inside?
The drug " Actemra " has a unique mechanism of action - it is a representative of the group of biological, genetically engineered drugs, i.e. it is the epitome of molecular medicine. Specially created molecules block one of the key pathways for the development of chronic inflammation. There is a substance called Interleukin 6 , and this drug allows the patient to block inflammation.
Block inflammation - firstly, from here - relieve swelling, relieve pain, this is the most important thing.
And the drug allows patients who have already been treated for a long time and who have, say, an insufficient response to many drugs that were previously used - standard chemical ones, this drug allows them to get a fairly good result.
Interleukin 6 is the main culprit in severe joint inflammation and cartilage destruction. It was to combat it that a new genetically engineered drug was created.
Actemra blocks Interleukin 6 and prevents it from destroying joints.
The inflammation goes away, the pain disappears and the person returns to normal life. It is very important that this medicine can and should be taken in the early stages of the disease, long before deformities occur. Only then can this arthritis really be cured and prevent the disease from damaging your hands.
Tell me, is it possible to take this medicine before such deformations occur?
In a good way, of course it is necessary, not possible, but necessary! Because if such drugs had been available back in the seventies, when Lyudmila fell ill, perhaps we would not have seen such a picture.
And so, friends, a new medicine is in the arsenal of doctors. For the treatment of rheumatoid arthritis, severe joint pain. Genetic engineering is radically different from everything we have had so far, it gives us the opportunity not to live to see severe changes and simply have normal joints.
– Talk about this with your doctor. We will be happy if this helps you.
I want to wish you (note – Lyudmila) health, good luck in treatment, continue treatment if necessary.
Of course, we are glad that rheumatologists came to us and told us about such a unique medicine. Thank you (note – D.E. Koroteev) very much.
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