Trental (Trental Pentoxifyllinum) is a vasodilator vasodilator , blocks adenosine receptors, increases cAMP of cellular structures, stimulates microcirculation, and enhances the rheological characteristics of blood.
Pharmacological group: antispasmodic, antiplatelet agent, angioprotector (improves microcirculation and reduces vascular tone).
Country of origin : India, Turkey, Hungary and other countries with branches of the transnational pharmaceutical company Sanofi-Aventis France.
Active element of the drug: Pentoxifylline (Pentoxyphyllinum), a white crystalline, water-soluble powder, a derivative of methylxanthine.
The medication reduces platelet aggregation, increases the degree of plasticity of the red blood cell film, reduces viscosity and dynamically dislocates oxygen molecules. Intravenous infusion of the drug Trental ensures an increase in collateral (lateral) blood circulation, the passage of plasma through the section, and promotes the growth of ATP in the cellular structures of the brain. The weakly expressed antispasmodic vasodilator property of the main element reduces peripheral vascular resistance and dilates the coronary arteries. Drug therapy leads to optimization of hemodynamic parameters, rehabilitation of peripheral veins, and reduces the likelihood of convulsive syndrome.
The formation of blood pressure and oxygen saturation of tissue is carried out by microvessels and capillaries (arterioles, venules). Maintaining microcirculation between them: collaterals (lateral vessels).
Calcium ions influence the interaction of the actin protein and myosin, ensuring the contractility of smooth and striated muscles. The passage of the blood duct narrows, the smooth muscles begin to contract intensely, and antispasmodic contractions (vasospasms) occur.
Trental blocks enzymes that hydrolyze the phosphodiester bond (PDE), changing the calcium content inside the cell matrix. The quantitative composition of calcium is influenced by cyclic adenosine monophosphate (cAMP), formed from adenosine triphosphoric acid (AMP) under the influence of adenylate cyclase enzymes. The active element (Pentoxifylline) blocks enzymes, increases the level of accumulation of internal cellular cyclic adenosine monophosphates, reduces the amount of calcium, relaxes muscle walls, increases vascular lumen, stabilizes blood flow and oxygen supply.
Round, biconvex tablet with white enteric film.
Tablets with prolonged action, biconvex, with a white soluble film. The genuine drug is marked with the engraving “ATA”.
Transparent liquid in 5 ml ampoules. and 15 ml.
Trental is characterized by accelerated absorption. The prolonged form of the tablets stimulates the constant movement of the active elements and uniform absorption of the sorbate. When administered orally, the active substances pass through the liver, being converted into pharmacological metabolites that are 5 (8) times greater than pentoxifylline. Metabolites are distributed evenly and are mainly excreted by the kidneys within 4 hours. With pathologies of the genitourinary system, the rate of excretion of metabolites decreases.
Trental, release form - tablets, instructions for use:
Average oral dosage: 1 (0.1 g) tablet three times a day, during or after meals. According to indications, over time the dosage increases to 0.2 g (2 tablets) every 6 hours. The maximum single dose can be no more than 0.4 g, the daily dose should not exceed 1.2 g.
Invasive routes of administration and doses:
IM injections: 5 ml (or 10 ml) ampoules; injections are given two to three times a day. Slow, deep administration of the drug is recommended.
Parenteral (boost) : 100 mg (1 ampoule) dissolved in 20 ml of sodium chloride, administered very slowly over at least 7 minutes, with the patient in a horizontal position. The procedure is repeated 3 times a day.
Parenterally (drip) is prescribed in a ratio of 10 ml (0.2 g of pentoxifylline) concentrate, previously diluted with 250 ml of sodium chloride or Ringer's solution. The drip is placed intravenously for 2-3 hours, with an interval of 10-12 hours. The period of infusion of a solution with 0.1 g (5 ml) of pentoxifylline should last at least an hour.
In the interval between droppers, 2 pieces of Trental (400 mg) are prescribed orally. For a one-time daily infusion: 3 tablets per day, of which 2 are taken in the middle of the day and 1 in the evening.
Symptoms of overdose are:
For uncomplicated symptoms, it is recommended to urgently take absorbents to cleanse the body: activated carbon in a ratio of 2 tablets per 10 kg of body weight.
The main actions in case of overdose: normalization of blood pressure, restoration of respiratory functions and prevention of seizures. If necessary, seizures can be stopped with Diazepam (invasively).
In case of gastric bleeding, convulsions, fainting and severe hypotension, urgent hospitalization is required. Self-treatment in these cases is unacceptable.
Contraindications for injections:
Relative restrictions, i.e. extreme caution is required when taking:
The official summary does not recommend taking Trental during pregnancy due to the lack of clinical trial data. The medicine is prescribed during the perinatal period if the benefit outweighs the potential harm to the health of the fetus.
Dosage and methods of administration:
The medicine is taken as a complex (additional) or individual therapy for uncomplicated pathologies of pregnancy.
The invasive method is indicated for hypertension and the presence of contraindications to taking pills.
From the second trimester of pregnancy, drip administration of the drug Trental is prescribed for placental insufficiency and Gestosis (a complication of the normal course of pregnancy). Spiral uterine arteries do not cope with the uteroplacental and fetal placental blood supply: kidney function is impaired, blood pressure increases, neurological and/or visual disorders, pulmonary edema and cyanosis occur. With minor FPN, the nervous system of the fetus is affected, and developmental delays begin. Severe disruption of blood supply leads to brain degeneration, premature birth and fetal death.
There have been no official clinical trials of the drug during lactation. According to the results of the examination, the active component is excreted in breast milk in minimal volumes. If indicated, the drug may be prescribed if the benefits outweigh the potential risks.
Use the drug only as prescribed by the attending physician.
Relative limitations may include individual characteristics of the body or chronic pathologies (dysfunction of the kidneys, liver, circulatory system).
Individual intolerance to components, exaggeration of the permissible dosage, parenteral administration with an increase in the recommended dose can cause side effects of Trental:
A large list of side effects requires constant monitoring of blood pressure levels, the functioning of the circulatory system, the functionality of the genitourinary organs, liver and gastrointestinal tract.
The following diseases and conditions require special monitoring:
Does not affect driving or other work requiring increased attention.
Smoking or drinking alcohol is not recommended when taking the drug:
Trental tablets should be stored in a cool, dry place (+15 C). Shelf life – 4 years from the date of release.
Ampoules with Trental concentrate: at temperatures below + 5 C. Use the suspension immediately after opening. Shelf life – 3 years.
All medications with identical pharmacological reactions contain pentoxifylline:
In addition to synonyms for the drug Trental, there are its analogues:
Trental is characterized as a good drug for the complex treatment of osteochondrosis, headaches of unknown origin, diabetic vascular damage, thrombophlebitis, stenosis, lupus erythematosus, hypoxia. Used as an additional therapy for recovery after stroke, myocardial infarction, etc.
The attitude of people in Trentalu is twofold. On the one hand, it helps well with various vascular problems, incl. normalizes the composition of hemoglobin, thins “thick blood”, and pathologies of the musculoskeletal system, while being inexpensive. On the other hand, it is poorly tolerated by many, causing nausea, vomiting, dizziness, shortness of breath and other side effects, as a result of which patients, in most cases, prefer to choose drugs that are more expensive, but with better tolerability.
Question: How dangerous is the risk of side effects when taking the drug? Answer: Before using the medication, it is necessary to carry out a diagnostic examination of the body. If there are restrictions, you should carefully select the dosage, do not exceed it and follow all recommendations of the treating specialist. Then the risk of complications is practically eliminated.
Question: Which is better Trental or Pentoxifylline? Answer: Trental contains the active substance pentoxifylline, but in addition to this, the drug contains components that optimize the pharmacological effect. This significantly improves mobility, bioavailability and the rate of elimination of half-life elements from the body.
Question: What to choose, Trental or Cavinton? Answer: Cavinton affects only the blood vessels of the brain, unlike Trental, which affects the entire vascular system.
Question : What is better to take, Trental or Mexidol? Answer : Mexidol is an antioxidant. These are medications with different directions. Complex therapy using these drugs has shown high effectiveness in the treatment of multiple sclerosis.
Question: What are the features of using Trental for osteochondrosis? Answer : The drug acts directly on the wall of blood vessels, increases passage and improves blood circulation. The optimal amount of oxygen and microelements begins to flow into the pinched tissue of the intervertebral disc, and natural tissue regeneration occurs. In acute stages, drip or intravenous administration is prescribed. To relieve pain, an intramuscular injection is made into the focal area.
Sale: by prescription
Storage: 15-25C (room temperature)
Shelf life: 48 months.
Trental (INN - pentoxifylline) is an original drug from the group of vasodilators from the Indian division of the world famous pharmaceutical company Sanofi. The first use of trental dates back to 1972, when it was used to treat intermittent claudication. In addition to the vasodilator, the drug has an antiplatelet (prevents platelets from adhering to each other) and angioprotective (protects blood vessels) effect. Due to its ability to improve blood fluidity, reduce platelet aggregation, stimulate capillary circulation and make red blood cells more elastic, trental has found wide use in various circulatory pathologies. The main “weapon” of trental, pentoxifylline, is very close in its chemical “pedigree” to theophylline and theobromine. All its pharmacological advantages are due to the exclusive possession of the secret inhibitory effect on type 4 phosphodiesterases, which entails an increase in the concentration of cAMP in platelets and ATP in erythrocytes against the background of a decrease in the content of calcium ions in cells. Numerous clinical studies conducted in accordance with all the rules of evidence-based medicine indicate the ability of trental to have a purely positive effect on microcirculation and blood circulation in general. And it cannot be otherwise: after all, this drug is capable of dilating blood vessels, simultaneously reducing their general and peripheral resistance, increasing stroke and minute blood volumes without a significant change in pulse rate.
The concentration of cAMP increases not only in platelets, but also in the smooth muscle cells of the vascular walls, which leads to their relaxation.
As already mentioned, Trental is a branded original drug. In the mid-2000s of the last century, a study of the rheological properties of trental in comparison with generic pentoxifylline preparations was carried out on the basis of Yaroslavl State University. At the same time, the original drug showed itself to be a more pronounced antiplatelet agent (46%) than generics (20-35%). Without exception, all drugs studied reduced the size and rate of formation of aggregates, but only trental showed a consistent and significant decrease in all aggregation characteristics.
Trental is available in three dosage forms: tablets, extended-release tablets and concentrate for the preparation of a solution for intravenous and intra-arterial administration. The frequency of administration and dosage regimen are established by the attending physician according to the individual characteristics of each individual patient. During the course of treatment using Trental, it is recommended to monitor blood pressure, and if the patient has recently undergone surgery, then systematic monitoring of hemoglobin levels and hematocrit is indicated. An important clarification: when administering trental intravenously, the patient must be in a supine position.
Microcirculation disorders due to varicose veins lead to swelling, chilliness of the legs, and sensory disturbances. To restore capillary blood circulation, the drugs Trental or Pentoxifylline are used, which is better, you can find out after comparing them.
Imported Trental contains pentoxifylline as an active ingredient. It is available in tablets with dosages of 100 and 400 mg. There is also a release form in ampoules.
The medication is an angioprotector, a means for improving microcirculation. Has the following medicinal effects:
This leads to the expansion of capillaries and restoration of microcirculation, reducing pain and cramps in the legs.
Prescribed for the treatment of venous insufficiency, as well as other vascular diseases accompanied by capillary circulation disorders. The dosage and route of administration are determined by the attending physician, taking into account the severity of the disease.
Side effects noted:
Trental is prescribed with caution to people with diseases of the stomach, liver and kidneys.
Contraindicated in the following situations:
Trental is dispensed from pharmacies with a doctor's prescription. Its price depends on the dosage and ranges from 300 to 700 rubles.
Domestic medicine. Contains pentoxifylline as an active ingredient. Available in 100 mg tablets and ampoules with a two percent solution.
Its mechanism of action is the same as that of Trental. Used for the same diseases. Side effects and contraindications do not differ from those of Trental.
The method of administration and duration of the treatment course are determined by the severity of the disease. Pentoxifylline injections are best administered intravenously.
The product is also available with a prescription, and its cost is slightly lower. A package of domestic Pentoxifylline will cost 100-150 rubles.
In terms of composition and mechanism of action, Trental and Pentoxifylline do not differ from each other. These are not different medications, Trental is the trade name for Pentoxifylline and is manufactured by a French pharmaceutical company. Pentoxifylline is an analogue of Trental and is a domestic product.
When answering the question whether to choose Pentoxifylline or Trental, you should take into account the quality of production of both products. The Russian analogue is of good quality considering its low cost. But Pentoxifylline is also produced by Ukrainian companies, where its price is even lower. The effect of this medication is much lower. Trental is produced in Indian and Swiss factories, using modern equipment and using modern materials. The quality of cleaning is significantly higher than that of Russian and Ukrainian analogues. The medicinal base of the tablets causes fewer allergic reactions. Trental injection solution undergoes better quality control.
The mechanism of action for both drugs is the same. While taking Trental, there is a faster restoration of blood circulation than with treatment with Pentoxifylline. This is confirmed by numerous studies that were conducted for imported products. Domestic Pentoxifylline did not have such studies.
For oral use, there is no significant difference between Trental and Pentoxifylline; both drugs can be used. But for intravenous use, it is still better to prescribe Trental, as a better and more effective medicine.
There are also no differences in ease of use, but Trental is available in a dosage of 400 mg, while Pentoxifylline does not have such a dosage. Therefore, if an increased dose is required, it is more convenient to take a Trental tablet rather than 4 Pentoxifylline tablets. This is especially convenient when the patient requires a long course of treatment.
The disadvantage of Trental is its relatively high cost. Not every patient can afford to purchase an expensive medicine and replaces it with an analogue called Pentoxifylline, which is cheaper.
Patients treat Trental and Pentoxifylline differently. Everyone has their own experience with these medications.
I have been suffering from varicose veins for a long time. A trophic ulcer has already formed on my leg, which is not going away. The doctor prescribed me a course of drips with Trental. Already by the fifth drip I began to notice an improvement, and by the end of treatment the ulcer was completely covered with a crust. I was satisfied with the medicine, there were no side effects.
Margarita Petrovna, 57 years old, Penza.
I have been diagnosed with varicose veins on my legs for several years. Recently, unpleasant sensations have begun to appear - crawling, tingling. I went to the doctor, he said that this is how circulatory disorders manifest themselves. He prescribed me to take Pentoxifylline tablets. The pharmacy offered an imported analogue, Trental, but it costs much more. I took Pentoxifylline for 2 weeks, the discomfort almost disappeared. I don’t regret that I didn’t take imported medicine.
Irina, 35 years old, Syzran.
I have varicose veins, and the doctor prescribed me a course of medications to improve microcirculation. He prescribed Trental and warned that there is a cheaper domestically produced analogue, Pentoxifylline. He said that it causes side effects more often. I decided to buy the drug cheaper. Three days later, a rash appeared on the skin and it began to itch. I decided to change to Trental. I've been on it for 10 days now, no reactions. Still, imported medicines are made of better quality.
Igor Petrovich, 44 years old, Murmansk.
From the reviews of doctors from Trentale and Pentoxifylline, it is clear that doctors prefer to prescribe an imported drug.
Among my patients with varicose veins of the legs, there are many who have microcirculatory disorders. This leads to the development of trophic ulcers, dryness and flaking of the skin. To restore microcirculation, I prescribe Pentoxifylline or Trental to such patients. I can’t say that the drugs differ significantly in action, but I noticed a peculiarity that for intravenous administration it is still better to use imported medicine. The tablets act almost identically and can be used in the initial stages.
Yulia Sergeevna, phlebologist, Yekaterinburg.
I have been using products to improve blood microcirculation in my practice for quite some time. I use both domestic and imported products. I try to recommend Trental to my patients, as I have noticed that the effect of its use comes much faster and is more pronounced. I prescribe Pentoxifylline only to those who cannot afford expensive medicine. This drug requires longer use to obtain the desired effect.
Irina Aleksandrovna, phlebologist, Tver.
Trental and Pentoxifylline are similar drugs in terms of active substance. Patients and doctors leave more positive reviews about the imported analogue, and among its disadvantages they only point out the relatively high price.
Burning in the legs is an unpleasant phenomenon and can be a symptom of serious diseases that need to be treated urgently. A burning sensation in the legs can occur once, be present constantly, or occur at a certain time. More often, this unpleasant sensation occurs in the evening or at night. Burning feet at night torment a person and prevent them from sleeping and resting normally.
The causes of burning in the legs can be external or internal.
External signs include:
Internal ones include:
To determine more accurately what disease is associated with burning legs, you need to listen to your body and pay attention to the accompanying symptoms.
Diseases that cause discomfort in the legs:
Leg pain is familiar to everyone. After a long walk or a promenade in high heels, many of us wince from painful sensations in our feet or calves.
But for some, the mentioned symptom persists quite persistently and, at the same time, regardless of the load received. Why do people's legs hurt? What to do if this attack becomes permanent? How to get rid of it and prevent relapse? We will talk about all this later in the article.
So your legs hurt. What to do, how to overcome the disease? Let’s make a reservation right away: there is no panacea; you need to have a clear understanding of the causes of unpleasant symptoms. After all, they can be triggered by many factors - problems with the spine or joints, disorders in the vascular system or diseases of the leg muscles.
But most often the described symptom is caused by circulatory problems, namely a violation of venous outflow and, as a consequence, an increase in pressure in the vessels. Venous congestion can cause irritation of nerve endings and pain. This pain is usually characterized as “dull”, making the legs heavy, “leaden” (especially in the evening), and most often it is a sign of developing varicose veins.
Another cause of discomfort is the presence of atherosclerosis. This pathology causes hardening of the walls of blood vessels, and this is what most often explains the occurrence of pain in the calf muscles. In this case, the compressive pain becomes especially noticeable while walking. By the way, one of the important signs of atherosclerosis is the constant feeling of cold feet, no matter how warm it is around.
If your feet hurt due to varicose veins, only a doctor can decide what to do. This disease is treated with drugs that improve blood flow in the vessels and regulate their tone (Ginkor-Forte, Detralex, Pentoxifylline, Trental, etc.), as well as anticoagulants - for example, heparin ointment.
If drug treatment does not help, surgical intervention is used - the affected veins are removed or solutions are injected that glue their walls together.
For atherosclerosis of the lower extremities, therapy is aimed at reducing pain and preventing blockage of blood vessels, which can cause ulcers and the development of gangrene on the legs. For this purpose, drugs that normalize cholesterol levels (Cholestyramine, Lovastatin) and nicotinic acid are prescribed. Sophora officinalis ointment is used as a local remedy.
But not only problems with blood vessels can cause your legs to hurt (what to do, this is a symptom of many diseases!). Thus, disturbances in the intervertebral discs can cause radiating (that is, radiating) pain in the lower extremities (by the way, the spine itself in such cases may not hurt). In addition, this symptom can appear many years after childhood back injuries or in people suffering from scoliosis.
The pain associated with joint pathology is of a special nature - it is strong, “twisting”. They are accompanied by swelling and redness in the affected area, and when the weather changes, there is usually an increase in discomfort. As a rule, the pain described is localized in the hip, knee or foot, and sometimes affects several joints at once.
So, in cases where the leg hurts above the knee (up to the hip), we can talk about arthrosis of the hip joint. And if discomfort in the knee leads to loss of mobility, then we have a picture of arthritis. By the way, one of its forms is gout. The pain with it is especially debilitating and protracted.
It should be noted that only a specialist can determine exactly what disease caused the constant pain in the legs. But in some situations the explanation is obvious.
We are talking about a fairly common disease, which is more susceptible to women over the age of 40, called hallux valgus. This pathology is the growth of a cartilaginous growth at the base of the big toe, causing the latter to bend, and the shape of the foot itself changes, causing a lot of trouble to the patient.
Therefore, if you have a painful bone in your foot and redness or abrasion of the skin appears on it, then you should immediately begin treatment for the disease, since in an advanced stage it is very difficult to get rid of this problem.
At the late stage of development of hallux valgus, the patient suffers from debilitating pain in the big toe and soles of the feet, the joints become inflamed, and corns appear. It becomes very difficult to choose shoes due to crooked toes and greatly enlarged bones; in addition, this pathology adversely affects the condition of the spine, as well as the knee and hip joints.
Treatment of any joint pain, regardless of whether the pain is in the ankles, knees or hips, should only be carried out under the supervision of a specialist. Self-diagnosis, as you understand, carries the risk of incorrectly assessing the extent of the lesion and determining the cause that caused it.
Having established an accurate diagnosis, the doctor prescribes therapeutic measures aimed at:
For this purpose, painkillers are prescribed (Ketanol, Ibuprofen), chondroprotectors designed to regenerate the cartilaginous structure of the joint (Chondroitin), as well as ointments that relieve inflammation (Fastum, Voltaren-gel, etc.). Infectious forms of arthritis require the use of antibiotics. And in some cases (for example, with severe hallux valgus or arthrosis), the patient is indicated for surgical intervention.
But often the problems do not manifest themselves as clearly as when a bone in the leg hurts. The patient may not suspect for a long time that pathological changes are occurring in his body. In particular, this applies to the well-known foot disease called flat feet - drooping of the longitudinal or transverse arch of the foot.
In medicine, there are 3 types of this pathology:
All these conditions develop gradually, leading to the patient’s foot shape changing (it becomes much wider, its arch flattening), the gait becomes heavy, the ankles and back ache, the legs often hurt at night, and swelling of the limbs that appears in the evening is also bothersome. and passing in the morning.
Another serious reason that can cause pain in the legs is inflammation (myositis) of the calf muscles. Its occurrence can be caused by an unusual load for the patient, trauma, hypothermia, infectious disease, as well as connective tissue pathologies.
With this type of myositis, the patient develops isolated redness on the skin of the lower extremities with a local increase in temperature, the legs hurt from the knee to the foot (especially in the calf area), muscle weakness appears, and the pain syndrome intensifies even with minor exertion.
A characteristic feature of the described disease are dense areas with individual nodular formations and cords that can be felt in the affected areas. However, an attempt at such palpation causes an increase in aching pain in the patient.
If your legs hurt from the knee to the foot, and you also discover other signs of pathology listed above, you should immediately consult a doctor.
The specialist, as a rule, prescribes bed rest in order to provide rest to sore muscles, and painkillers (Voltaren, Ketonal, etc.). Anti-inflammatory drugs with a warming effect (Dolex, Apizatron, Fanigan, etc.) are usually used as local therapy. If infection is present, antibiotics are prescribed.
As you can see, the list of reasons that can cause leg pain is quite impressive. Therefore, if you are suffering from the described symptom, go to the doctor. Start with a therapist, and if necessary, he will refer you to an orthopedist or neurologist.
Of course, you can carry out some therapeutic measures yourself, but keep in mind that they will not relieve you of the disease, but will only alleviate the condition for a while.
So, if your legs hurt or ache, then warm baths with the addition of Epsom salt are a good remedy. After them, by the way, you need to rinse your feet with cool water and lubricate them with moisturizer.
Contrast dousing of the feet also helps a lot. To do this, you should alternately hold them under running hot and cold water (for a minute for each dousing). Finish the procedure with cold water.
Fir oil is also a good remedy. It is rubbed into the areas of pain after taking a bath for 10-15 days.
If your knees hurt, your calves ache, or your feet hurt, it’s not difficult to understand what to do: you need to undergo an examination by a specialist and, following his recommendations, get rid of the disease that causes the pain.
After all, all its types are provoked by different reasons, accordingly, they need to be treated with different methods. You should not choose your own medications. This can only aggravate the disease or distort its symptoms, which subsequently prevents a correct diagnosis. Don’t risk your health, consult a doctor on time, and your legs will thank you with an easy walk! Be healthy!
The variety of trade names for drugs sometimes confuses patients. Patients with varicose veins are often interested in what is better than Trental or Pentoxifylline for manifestations of vascular insufficiency. After carefully reading the instructions, you can understand that Trental is Pentoxifylline. In this case, the pharmaceutical company used the original name, which belongs to a specific manufacturer.
Pentoxifylline and Trental belong to the group of angioprotectors that improve blood microcirculation. Medicines dilate blood vessels and improve nutrition of tissues and organs. Instructions for medications can be easily compared in table form.
Pentoxifylline is an analogue of Trental, which means that it is no less effective in the treatment of venous insufficiency. Clinical trials of the drugs have proven their positive effect on blood vessels and circulation. The products are well suited for the treatment of severe manifestations of varicose veins with impaired trophism. Unlike external agents, Trental and Pentoxifylline can be used in the presence of wounds and open ulcers.
As a result of comparing the drugs, it turned out that they differ only in price and manufacturer. The presence of Pentoxifylline in a ready-made solution form, which Trental does not have, makes its use more convenient. Otherwise the drugs are identical.
When choosing Pentoxifylline or Trental, you need to trust the opinion of your doctor. He will prescribe the required form, determine the therapeutic concentration and safe dosage.
Reviews from doctors about Trental and Pentoxifylline, as well as from patients, are varied.
Trental and Pentoxifylline have a good therapeutic effect when there is a threat of thrombosis. The drugs combine well with external venotonics. Patients respond to both drugs equally. But I try to prescribe Trental less often due to its high cost.
Oleg Alekseevich, phlebologist, Kostroma
I use these drugs minimally in the treatment of varicose veins. There are too many complaints about side effects, especially in elderly patients and diabetics.
Natalya Ivanovna, vascular surgeon, Kurgan region
I received a prescription for Trental due to thrombophlebitis. I don’t know how it affected my veins, but after two weeks I was forced to quit treatment. It causes terrible morning sickness and insomnia.
Tatyana Vasilievna, Rostov-on-Don
A very good remedy for varicose veins. I completed a course of intravenous infusions and immediately felt relief. Previously, there was heaviness in the legs and cramps. I didn’t feel any side effects, only my stomach ached a little. But after finishing the course of treatment everything went away.
Our legs are a network of venous and arterial vessels. Through arteries, blood travels to tissues, supplying muscles and ligaments with oxygen and nutrients. And veins are necessary to return fluid back to the large blood circulation. As a result of some diseases, blood circulation in the legs may deteriorate.
In this article we will talk about this problem in detail.
Artery problems occur in people who smoke a lot. Nicotine affects the inner layer of blood vessels, stimulating the progression of atherosclerosis. When the notorious “plaques” appear in the iliac arteries, the blood supply to the legs is greatly deteriorated. The patient suffers from cramps, complains of constantly cold feet, the appearance of age spots and ulcers. Similar symptoms are observed in patients with diabetes, autoimmune vascular diseases, and obesity.
What medications will improve arterial blood supply in the legs? Means for stimulating arterial nutrition should perform the following functions:
Anticoagulants are prescribed only by a doctor. These drugs sometimes require monitoring to determine the correct dosage. For arterial insufficiency, Aspirin, Cardiomagnyl, Heparin, Clopidogrel are used. Thanks to these drugs, the blood becomes liquid, there is no accumulation of cells that provokes the growth of atherosclerotic “plaque”. The dose and course of treatment with anticoagulants is determined by the doctor after laboratory and instrumental studies. Sometimes these drugs are prescribed for life.
The drug Pentoxifylline or Trental has a vasoactive effect. It not only affects vascular tone, but also improves blood rheology. Thanks to it, the activity of inflammation that occurs in the atherosclerotic “plaque” decreases. Blood cells become stronger and more flexible. Consequently, when passing through the capillaries, they do not collapse and do not clog their lumen. Trental improves blood circulation not only in the legs. It is used for stenosis of any peripheral vessels (including the arms).
Prostaglandins are used to dilate capillaries and arterioles. They increase the vascular lumen and suppress the “clumping” of blood cells. Treatment with prostaglandins is carried out only in a hospital. Actovegin helps eliminate tissue ischemia of the lower extremities.
Important! If arterial vessels are damaged, it is necessary to stop smoking and follow a low-cholesterol diet. Otherwise, the effect of drug treatment will be minimal.
This type of pathology occurs when there is poor blood circulation through the veins. Fluid stagnates in the vessels of the lower extremities, swelling, trophic changes in the skin, and ulcerative defects form. Often the disease manifests itself as cosmetic defects - enlarged protruding veins that spoil the appearance of the leg.
In what cases does venous insufficiency occur? The most common cause of this is varicose veins of the lower extremities. It is provoked by age, excess weight, hormonal imbalances, taking contraceptives, heredity and pregnancy. It is not surprising that in most cases, females suffer from this pathology. The following drugs are used to treat venous insufficiency:
Venous insufficiency can occur due to thrombosis of the superficial and deep veins of the lower extremities. A dense thrombus disrupts the movement of blood in the venous system, causing pain, swelling, and redness of the skin. In some cases, this condition can become life-threatening.
To treat venous pathology, venotonic agents are needed. The most effective medicine today is the substance diosmin.
Diosmin is a substance of natural origin, a bioflavonoid.
The original drug for diosmin is Detralex. To treat vein diseases, 2 capsules of this substance are used. The course of therapy is prescribed individually in each case. You can also use cheaper analogues of diosmin - Phlebodia, Venarus, Normoven.
Anticoagulants in the treatment of venous insufficiency are important for the prevention of thrombosis. Blood circulation in varicose veins is disrupted due to defects in the venous wall and insufficiency of the vein valves. Therefore, the fluid flow in the vessels occurs with turbulence, which contributes to the development of thrombosis. Substances such as Aspirin, Heparin, Polocard prevent the formation of blockages in the venous system.
In the treatment of varicose veins, which have progressed to the stage of trophic skin changes, it is necessary to use medications such as Pentoxifylline. We described its properties above. And of course, treatment of varicose veins of the lower extremities is impossible without ointments and gels. External medications (Troxevasin-gel, Heparin-gel, Lyoton-gel) relieve muscle tension, improve blood circulation and reduce leg swelling.
Traditional healers suggest not limiting yourself to medicines. Movement is important for a quick recovery. In case of arterial insufficiency, daily walking is mandatory. Of course, long distances cause severe discomfort in the patient. But regular short walks will be beneficial. If you have varicose veins of the lower extremities, it is not recommended to sit or stand for long periods of time. But walking without load will improve the outflow of blood from the veins. Physical exercises are also useful for varicose veins (prone bicycle, birch bike, flexion and extension of the foot).
To treat cold feet, traditional healers use “hot” herbs. This is garlic, red pepper, ginger. Garlic can be effectively consumed as a seasoning. You can prepare an alcohol tincture from red pepper (one pepper per 100 grams of vodka) and rub it on your limbs. Ginger is suitable for making drinks. One slice of fresh root added to tea can dilate peripheral blood vessels and increase blood flow.
For venous problems, the most effective plant is horse chestnut.
It contains substances that normalize the tone of venous vessels. You can prepare a tincture from the flowers (200 ml of vodka is poured from the fresh plant and infused for about a month), and the fruits can be used to make an ointment (chop 5 ripe chestnuts and pour a glass of vegetable oil, cook the mixture for 2 hours in a water bath). The tincture is taken orally, 25-30 drops, the ointment is used for rubbing and adding to contrast baths.
So, in this article we have told you how to improve blood circulation in your legs. Not only pharmaceutical drugs, but also folk recipes can cope with the treatment of this pathology. The main thing is to know the correct diagnosis.
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