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Tablets for arthrosis of the knee joint

07 Jul 18

Medicines for arthrosis of the knee joint

Arthrosis of the knee joint is a disease that causes discomfort and discomfort in life. Severe pathology occurs in every fifth person, but much more often the disease affects the body of women. This is due to the peculiarities of changes in their body after forty years. Having discovered that you have a knee disease (gonarthrosis), you must immediately contact a specialist so that he can prescribe the right medications for the unpleasant arthrosis of the knee joint. Let’s take a closer look at what medications an experienced doctor can prescribe.

What medications are taken for arthrosis of the knee joint?

A person experiencing pain associated with gonarthrosis for the first time may not even understand that this disease is present in the body. If unpleasant sensations occur after a long stay in one position or immediately after waking up, and pass during the day, this is the first stage of the development of pathology. At the second stage, the pain comes more often, becomes more intense, while walking a man or woman may feel discomfort or even severe pain, and a peculiar sound is often heard in the knee - a creaking sound. During palpation, a person feels pain.

The third stage is the final stage of the disease, when the knee joint can no longer be fully restored. In this case, the patient experiences constant excruciating pain, his temperature may rise, it becomes difficult to move, and lameness appears. To avoid serious consequences, you need to diagnose it in time and see a specialist. In addition to medications, there are other options for reducing pain and treating gonarthrosis:

  • Cane. A person experiences the most severe sensations with gonarthrosis while walking. This is due to the stress that the body places on the knee joints. To significantly reduce it, you need to use special crutches or a cane. It is advisable to choose a cane with a rubber attachment, which will eliminate the possibility of slipping. The ideal length of the product is from the wrist (when the hand is lowered) to the floor.
  • Exercise and diet. Often the development of the disease is associated with an unhealthy lifestyle, obesity, and sedentary work. To speed up the healing process, you need to start eating right and getting enough vitamins in your food. Therapeutic gymnastics will help get rid of gonarthrosis, but it is allowed to do it only after the inflammation has subsided.
  • Physiotherapy, manual therapy. These methods will help restore nutrition to the damaged joint; more blood will flow to the sore knee, helping a speedy recovery. After the massage, the patient will experience significant relief, but these procedures cannot be performed during an inflammatory process.
  • The range of drugs is extensive during the treatment of gonarthrosis. Doctors prescribe special compresses, ointments, tablets, and intramuscular injections to their patients. There are two main effective groups of remedies that help get rid of an unpleasant pathology; they differ in the method of action. It is necessary to take medications according to the stated dosage, after the recommendation of the attending physician. If you are sick, you should never self-medicate.

    Nonsteroidal anti-inflammatory drugs

    A non-steroidal group of anti-inflammatory drugs are drugs that do not contain hormonal substances. These medications are the first aid for illness. Various non-steroidal medications can remove the symptoms of the disease: cope with pain much faster, relieve tissue inflammation. The effect also differs in significance from the type of drug: some have a more anti-inflammatory effect (ibuprofen, aspirin, amidopyrine), others have an analgesic effect (diclofenac, ketoprofen, indomethacin).

    The peculiarity of the action of non-steroidal drugs is that they only help relieve the main symptoms of the disease, but do not contribute to a complete cure of the knee. As soon as the inflammation subsides, the person should stop taking these medications. The absence of obvious symptoms may be mistakenly perceived by a sick patient as recovery, and non-steroidal medications have unpleasant side effects for the body:

  • Long-term use of such drugs can affect the body's water balance, which will lead to dehydration of the cartilage in the knee joint. In this case, arthrosis will progress even faster.
  • NSAIDs (non-steroidal anti-inflammatory drugs) can have a negative effect on the stomach. Often, long-term use of such medications is accompanied by the appearance of problems with the gastrointestinal tract (gastrointestinal tract) - erosive, ulcerative pathologies, gastritis. Those who already suffer from similar diseases should be especially careful.
  • The rate of blood flow in the kidneys may be impaired. This will contribute to the accumulation of salts, increased blood pressure, and, as a result, heart problems.
  • Cardiovascular diseases can also be triggered by anti-inflammatory drugs. If used incorrectly, thrombosis, stroke, and heart attack may occur.
  • The second main group of drugs in the treatment of arthrosis are chondroprotectors. Unlike non-steroidal anti-inflammatory drugs, they not only help to significantly reduce the unpleasant manifestations of gonarthrosis, but also help to effectively treat the pathology. Such drugs are considered relatively safe and do not have serious side effects, but they must be taken with caution and after a doctor has written a prescription. They are an essential part of effective treatment of gonarthrosis.

    The principle of action of the drug is to help the body's recovery processes. Thanks to the use of these medications, blood circulation in the area of ​​the affected knee joint improves, joint fluid begins to be produced in normal quantities, and its lubricating properties return to normal. Subtleties of treating arthrosis with chondroprotective drugs:

  • You should not expect a quick cure with this type of medication. Chondroprotectors do not begin to help immediately. The duration of treatment varies from six months to a year, and the first positive changes are noticeable only after several months.
  • The effect of medications will be exclusively in the first two stages of gonarthrosis. In the third, the cartilage tissue affected by chondroprotectors can no longer be restored, because it is completely destroyed.
  • There are two types of chondroprotectors - chondroitin sulfate and glucosamine, on the joint use of which experts do not yet have a consensus. Some scientists even claim that these drugs can weaken each other's effects.
  • Effective drugs

    After consultation with a specialist, it is necessary to purchase medications for painful gonarthrosis. The cost of drugs varies depending on the manufacturer, the quality of the substances in the composition, and the pharmacy. There are products both at a high price and their inexpensive analogues, differing only in name. Let's consider the best effective non-steroidal anti-inflammatory drugs and chondroprotectors.

  • Ingredients: active ingredient – ​​diclofenac sodium + excipients.
  • Indications: helps with inflammatory, degenerative pathological changes in the musculoskeletal system. The drug is effective for arthrosis and arthritis. It has a pronounced anti-inflammatory effect, produces an analgesic effect, and relieves fever.
  • Application: dosage is prescribed individually depending on the course of the disease. For adults, 25-50 mg of the drug is prescribed when taken orally 2-3 times a day.
  • Price: 40-100 rubles.
  • Ingredients: chondroitin sulfate + glucosamine hydrochloride.
  • Indications: the medicine is an indispensable tool in the fight against gonarthrosis; it is prescribed for osteochondrosis of the spine and other diseases associated with dysfunction of cartilage tissue. Available in tablets.
  • Application: in tablets of 250 milligrams - 2 pieces 2 times a day, 500 mg - 1 twice a day, 750 mg - 1-2 pieces.
  • Price: 670-1600 rubles.
  • Ingredients: glucosamine sulfate + excipients.
  • Indications: helps in the treatment of gonarthrosis and other diseases of cartilage tissue. The active substance of the medicine restores normal metabolic work in the cartilage, promotes its better nutrition and good “lubrication”. Reduces pain by inhibiting degenerative processes.
  • Application: powder (in a sachet) - one packet once a day for one and a half months, injections - 1 ampoule 3 times a week.
  • Price: 1100-1200 rubles.
  • Ingredients: glucosamine + auxiliary elements.
  • Indications: for negative processes in cartilage tissue. The medicine helps to cope with arthrosis of the knee joint, producing an anti-inflammatory and analgesic effect. Stimulates restoration processes in cartilage tissues.
  • Application: the drug is administered intramuscularly. Two milliliters of Elbona with a solvent are used, administered once a day three times a week. Course duration is 1-1.5 months.
  • Price: 1200-1400 rubles.
  • Ingredients: sodium chondroitin + sodium salt.
  • Indications: this chondroprotective medicine helps the patient to quickly cope with arthrosis of the knee joint, restoring cartilage tissue and improving its nutrition. Has an antioxidant effect and helps cope with inflammation.
  • Application: the drug is used in capsules, the recommended dose is 1000 milligrams.
  • Price: 1400-1500 rubles.
  • Ingredients: chondroitin sodium + glucosamine hydrochloride.
  • Indications: a combined medicine that helps slow down the destructive processes affecting human cartilage tissue, which helps to more quickly treat arthrosis of the knee joint. Reduces discomfort, relieves inflammation.
  • Application: for the first 20 days, 1 tablet 3 times a day, then two. The course lasts 2-3 months.
  • Price: 1000-1500 rubles.
  • Ingredients: chondroitin sulfate + auxiliary elements.
  • Indications: the medicine is indicated for people suffering from arthrosis of the knee joint of the first and second degree. The drug helps get rid of inflammation, pain, promotes restoration processes that return cartilage tissue to health, and improves metabolic processes.
  • Application: every other day, 1 ampoule of the drug intramuscularly.
  • Price: 1200-1300 rubles.
  • Ingredients: chondroitin sulfate + excipients.
  • Indications: the medicine promotes the regeneration of damaged tissues, helps cope with inflammation, and reduces pain symptoms. Improves metabolic processes occurring inside fibrous and hyaline cartilage.
  • Application: 2 tablets (0.5 grams) 2 times a day.
  • Price: 300-500 rubles.
  • Ingredients: chondroitin sulfate sodium + auxiliary elements.
  • Indications: used for osteochondrosis, cartilage damage, arthrosis of the knee joint. Helps reduce inflammation, relieve severe pain, improves metabolism occurring in cartilage tissues. Stops degenerative processes.
  • Application: 1000 mg per day (2 tablets 2 times per day).
  • Price: 60-300 rubles.
  • Tablets for arthrosis of the knee joint: 16 best drugs

    Any disease cannot be cured without the use of medications. Each category of medicines is intended for specific purposes. In the article we will talk about tablets for arthrosis of the knee joint, their categories, and purpose.

    Categories of drugs for arthrosis

    When diagnosing arthrosis of the joints of the extremities, traditional treatment (a course of medications in combination with physiotherapy) or surgical intervention (for an advanced stage of the disease) can be prescribed. The doctor decides which treatment method to use after diagnostic studies.

    Regardless of the degree of development of arthrosis, initial therapy, or in the postoperative period, begins with taking tablets for the treatment of the knee joint. All drugs prescribed for the pathology of an injured limb are divided into the following categories:

    1. painkillers with anti-inflammatory effect;
    2. hormonal drugs (glucocorticosteroids);
    3. chondoprotectors;
    4. means for replacing and restoring synovial fluid.
    5. In this article we will talk about tablet medications and touch on other forms of medications (injection solutions, ointments, gels).

      Painkillers

      Any medications for joint arthrosis can only be used as prescribed by a doctor. Painkillers for arthrosis of the knee joint are usually prescribed for a short course. The short-term use is explained by the fact that the drugs have many contraindications, do not cure the pathology, but only eliminate the pain syndrome.

      Common pain relievers for knee arthrosis include the following:

      • Indomethacin . The tablets effectively eliminate pain, fever and inflammation;
      • Aspirin is prescribed mainly for acute arthrosis. The drug is considered the most common non-steroidal drug, which not only relieves pain, but also prevents the further development of inflammation of the joint of the injured limb;
      • Ibuprofen also relieves pain and reduces inflammation;
      • Phenylbutazone is one of the most effective non-steroidal drugs that relieves severe, persistent pain and swelling in the sore knee. While using the medicine, you should not eat salty foods, because the active components of the medicine can retain fluid in the body;
      • Corticosteroid (hormonal) drugs are prescribed if the painkillers listed above for arthrosis of the knee joint do not have the expected effect.
      • The dosage of medications is prescribed depending on the stage of the disease and the general well-being of the patient. The individual characteristics of the body with concomitant diseases are also taken into account.

        Other remedies to combat arthrosis pain

        Pain relief for arthrosis of the knee joint is performed not only with the help of tablets. If it is necessary to get rid of pain faster, then painkillers, intra-articular or intramuscular injections are given. Solutions for injections into the muscle include the following drugs:

      • analgesics used to relieve pain;
      • antispasmodics (Mydocalm), which weaken muscle spasms and at the same time provide an analgesic effect;
      • non-steroidal injection solutions of Ibuprofen and Ketonal relieve pain and inflammation;
      • steroid solutions have an effective effect on the diseased limb, eliminating pain and restoring motor activity of the knee.
      • Injectable anesthetic solutions that are placed directly into the joint include:

      • hormonal agents (corticosteroids). For example, Flosteron almost instantly relieves pain, but does not cure the disease. Usually prescribed in combination with vitamin groups;
      • Novocaine. With the help of this well-known painkiller, a blockade is made. The drug can be used infrequently (no more than 3 times a month), and is combined with vitamins.
      • Anesthetic ointments, like other forms of drugs, are not able to eliminate the disease itself. With their help you can only temporarily relieve pain. But, compared to tablets, ointments do not have a negative effect on internal organs during use. Ointments only affect the specific area to which they are applied. This is their advantage.

        The following ointments are mainly prescribed to relieve pain due to arthrosis:

      • Voltaren, where the main component is Diclofenac;
      • Fastum gel;
      • Ketonal is considered an effective pain reliever;
      • Nise. The effect of the ointment is similar to Nimesulide tablets;
      • Dolgit helps to quickly get rid of pain and swelling in the knee area. The main ingredient is Ibuprofen.
      • How to treat arthrosis of the knee joint and what pills to prescribe is decided by the doctor in each specific case. There is no single template according to which the pathological process is treated for such a serious disease as arthrosis. Each case is individual.

        Sometimes in combination with traditional drug treatment, home treatments are additionally used for treatment. These are all kinds of compresses, homemade ointments, decoctions and infusions from herbal preparations. Before using a home remedy for knee arthrosis, you should consult your doctor. Even if permission is received, you cannot stop taking the medications prescribed by your doctor.

        How to forget about joint pain forever?

        Have you ever experienced unbearable joint pain or constant back pain? Judging by the fact that you are reading this article, you are already familiar with them personally. And, of course, you know firsthand what it is:

      • constant aching and sharp pain;
      • inability to move comfortably and easily;
      • constant tension in the back muscles;
      • unpleasant crunching and clicking in the joints;
      • sharp shooting in the spine or causeless pain in the joints;
      • inability to sit in one position for a long time.
      • Now answer the question: are you satisfied with this? Can such pain be tolerated? How much money have you already spent on ineffective treatment? That's right - it's time to end this! Do you agree? That is why we decided to publish an exclusive interview in which the secrets of getting rid of joint and back pain are revealed. Read more.

        How to give injections into the knee joint for arthrosis: drugs for intra-articular injections and features of the procedures

        Osteoarthritis of the knee joint often occurs in elderly patients. Degenerative-dystrophic changes worsen the condition of cartilage and bone tissue, limit the mobility of the affected knee, and change the usual rhythm of life.

        Drugs of various dosage forms help eliminate negative symptoms and slow down the destruction of cartilage: tablets, gels and ointments, injections. For arthrosis of the knee joint, the doctor will select effective medications with the most beneficial effect on the problem area.

        Reasons for the development of the disease

        Aseptic damage to joints occurs against the background of natural aging of the body. High loads, heavy lifting, and injuries of various types have a negative effect on cartilage tissue.

        The gradual destruction of cartilage increases friction of the articular heads, the process of synovial fluid production is disrupted, and the risk of inflammation increases. With severe damage to the knee joint, the patient loses the ability to move independently and constantly experiences severe pain.

        Factors that provoke the destruction of articular tissues in the knee area:

      • increased loads, frequent lifting of weights;
      • overweight;
      • changes in joint tissue associated with old age;
      • hormonal imbalance in menopausal women;
      • bruises, displacement of the kneecap, injuries to the meniscus and ligaments in the knee joint;
      • lack of stress on parts of the musculoskeletal system, low physical activity;
      • hard physical labor;
      • poor nutrition, minimal amount of foods that are good for joint health;
      • vitamin deficiency;
      • chronic pathologies;
      • diseases of the musculoskeletal system;
      • inattention to the health of the joints and spine, neglect of doctor’s advice.
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        Injections for arthrosis of the knee joint

        Injections are the optimal form of using medicinal compounds for severe pain in the knee joint. Delivery of drugs occurs almost instantly, the harmful effects on the gastrointestinal tract are minimized.

        Injections into the joint area are a rather unpleasant procedure. The benefits of administering potent anti-inflammatory compounds, painkillers and chondroprotectors are much greater than the discomfort.

        Various groups of medications help restore the health of the affected joint:

      • hormonal agents;
      • chondroprotectors;
      • compounds that improve blood circulation;
      • B vitamins;
      • muscle relaxants.
      • Injectable medications have a positive effect on the affected joint tissue:

      • blood circulation is normalized;
      • pain decreases;
      • the joint is stimulated;
      • swelling of muscle fibers decreases;
      • mobility of the problem area improves.
      • difference from other forms of medicines - rapid delivery of the active substance to the lesion during injections;
      • when the compositions are introduced directly into the area of ​​the affected knee, there is minimal negative effect on the mucous membranes of the stomach and intestines;
      • the active components of the medicinal solution begin to act immediately, without loss of medicinal properties while passing through food debris in the stomach.
      • Features of application

        Despite the high effectiveness of intra-articular injections, there are restrictions, in the presence of which it is prohibited to give injections to the knee for arthrosis. The patient is obliged to tell the doctor about chronic diseases and answer questions regarding their health status.

      • blood diseases: hemophilia;
      • deformation of the joint, which does not make it possible to correctly insert the needle into the intra-articular gap without damaging adjacent tissues;
      • increased sensitization of the body, negative reaction to the active substance or other components of the drug;
      • bacterial and viral infections;
      • diagnosed oncological pathologies;
      • dermatological diseases of an infectious nature.
      • Rules for injections

        The use of a medicinal solution in the area of ​​a problem joint requires a highly qualified doctor. Incorrect needle insertion and ignoring contraindications often provoke complications and worsen the course of joint pathology.

      • taking into account restrictions for injections;
      • selection of the optimal drug based on the severity of the case and the patient’s condition;
      • the doctor’s confidence in his abilities and skills;
      • assessment of the benefits and negative effects of the drug;
      • determination of the most affected area;
      • an allergy test is required before starting the procedure;
      • in case of deformation of cartilage and bone tissue, sharp narrowing of the joint space, injections are carried out under ultrasound control.
      • Review of effective drugs

        Not all drugs reduce pain in the affected area. Rheumatologists and orthopedists use several groups of medications that alleviate the pathological process of arthrosis.

        Potent drugs are “first aid” for acute pain. Injection solutions do not treat arthrosis, they only relieve severe pain. Glucocorticosteroids combine well with medications for the complex treatment of degenerative changes. The compositions have many side effects, injections are carried out in short courses, sometimes only 2-3 injections per month. Medicines have a wide range of prices.

      • Ketorolac. Rapid pain relief (blocking prostaglandin synthesis), negative effects on the heart and blood vessels.
      • Flosteron. It helps even with unbearable pain, but has a negative effect on many organs.
      • Hydrocortisone. The drug inhibits nerve sensitivity and reduces pain in the affected area.
      • Loracort. An effective remedy quickly relieves pain, but has a negative effect on the nervous and cardiovascular systems.
      • Effective medications with a positive effect on the affected knee joint. Chondroprotectors nourish weakened tissues, stop the destruction of intra-articular structures, and stimulate the process of cartilage regeneration.

        Injections into the knee with chondroitin sulfate and glucosamine are carried out in courses. Depending on the severity of the pathology, from 4 to 15 injections are required. There are practically no side effects; sometimes there is an allergy to the components of the medicinal solution.

        The following drugs received positive reviews:

      • Don. Actively affects cartilage tissue, nourishes, accelerates cartilage regeneration;
      • Elbona. A modern remedy with glucosamine. The drug reduces the looseness of cartilage tissue and suppresses inflammation.
      • Alflutop. An effective product that nourishes cartilage and stops the destruction of connective tissue.
      • Chondrolone. Nourishes, slows down degenerative-dystrophic processes. The drug is not recommended for infectious skin lesions. A course requires up to 25 injections.
      • Hyaluronic acid injections

        The natural remedy has virtually no restrictions on its use and rarely causes side effects. Hyaluronic acid actively nourishes cartilage, envelops joint structures with a thin film, and prevents excess friction. A positive property is maintaining water balance.

      • Ostenil. A popular remedy for the treatment of arthrosis of the knee joint. The drug is not used for pathologies of the liver, kidneys, or severe nervous disorders.
      • Fermatron Plus. The medicine not only treats sore joints, but also relieves pain. The disadvantage is the high cost.
      • Hyalux. An effective remedy for the treatment of arthrosis and arthritis. Some patients experience allergic reactions, but the positive effects explain the popularity of the drug.
      • Synocrom. An effective medicine for the treatment of chronic arthrosis in the knee joint area.
      • Vikosil. It has a positive effect on weakened cartilage, restores elasticity to tissues, and stops negative processes. The drug is effective in the acute stage of joint pathologies.
      • Injections are used to restore neurohumoral regulation. The complex of vitamins B1, B6 and B12 has a positive effect on cartilage tissue and reduces pain in the manifestations of arthrosis. Medicinal solutions are administered intramuscularly, but without the use of these drugs it is impossible to relieve patients from severe pain or prevent convulsions and spasms of tense tissues.

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        In some cases, doctors prescribe intramuscular injections of essential vitamins. The drugs are administered according to a special scheme: the first day - vitamins B12 and B1, the second day - vitamins B12 and B6.

        Cost of medicines

        The disadvantage of many modern drugs with glucosamine, hyaluronic acid and chondroitin is their high cost. Lower-priced drugs often have more side effects.

        Injections of chondroprotectors are also not cheap. Considering the duration of the course of treatment, the need to repeat therapeutic procedures throughout the year, the price for some patients turns out to be unaffordable, many interrupt treatment. Glucocorticosteroids are used infrequently, but the cost of some drugs is also quite high.

      • Chondrolone lyophilisate No. 10 – 870 rubles.
      • Fermatron Plus - 3500–4500 rubles.
      • Ostenil implant, 20 mg – 3700 rubles.
      • Gyalux, 2 mg – 4000 rubles.
      • Sinokrom, syringe tube 2 ml – 4300 rubles.
      • Don - 1400 rubles for 6 ampoules.
      • Elbona 200 mg/ml, No. 6 – 1100 rubles.
      • Ketorolac No. 10 – 70 rubles.
      • Loracort No. 10 – 1250 rubles.
      • Hydrocortisone suspension for injection, 5 ml, 125 mg of active ingredient, No. 1 – 210 rubles.
      • Alflutop, solution for injection, 10 ampoules – 1,750 rubles.
      • More detailed information about intra-articular injections for arthrosis can be found in the following video:

        Tablets for arthrosis of the knee joint

        Arthrosis is called degenerative-dystrophic changes in the joints due to damage to the cartilage tissue that covers the articular surfaces of the bones. The most vulnerable are the knee and hip joints, which are more often susceptible to this pathology than others.

        Arthrosis of the knee joint is a localized form of the disease and is called gonarthrosis. Its leading symptom is aching pain and discomfort that occurs after walking. Most often, knee arthrosis develops against the background of an injury that disrupts the internal structure of the joint.

        As a result of the loose connection of bones to each other, individual sections of cartilage experience increased stress, which leads to their rapid and premature wear. The destructive process goes through 3 stages, the manifestations of which can differ significantly.

        Pain in the initial stages is transient, and no other symptoms are observed yet. However, when gonarthrosis moves to the next stage, the situation changes sharply for the worse: the pain syndrome does not go away even after a long rest and bothers the person almost constantly. The functionality of the joint also decreases - mobility is limited, muscles weaken, and a crunching sound is clearly heard when bending the leg.

        According to statistics, it is at the second stage that patients most often consult a doctor, since the quality of life noticeably decreases. Treatment during this period in most cases allows one to achieve good results with the help of injections or tablets for arthrosis of the knee joint.

        Lasting positive dynamics are ensured only under the condition of an integrated therapeutic approach, when physiotherapy, exercise therapy, and a therapeutic diet are prescribed in combination with medications. The most important aspect of recovery is to reduce the load on the diseased joint, as well as the use of special orthopedic devices and normalization of body weight.

        Relieving pain and inflammation

        Treatment with conservative methods should solve several problems at once, the primary of which is the reduction or complete elimination of pain. In parallel or after acute symptoms are relieved, medications are prescribed to restore articular cartilage and activate local blood circulation.

        For arthrosis of the knee joint, non-steroidal anti-inflammatory drugs are traditionally used:

        Diclofenac is one of the best representatives of the NSAID class and combines anti-inflammatory and analgesic effects with good tolerance by patients

        However, we must remember that painkillers create a deceptive impression of cure, “masking” the manifestations of the disease. In other words, NSAIDs do not treat the disease, but stop its manifestations. In addition, recent studies have provided evidence of a negative effect of NSAIDs on the production of proteoglycans.

        Proteoglycans are complex protein compounds that participate in the formation of connective tissue and serve as a lubricant for joints. When their synthesis is disrupted, cartilage tissue loses moisture and becomes dehydrated, and the destructive process accelerates.

        Long-term use of painkillers significantly increases the risk of side effects. When prescribing them, it is necessary to take into account possible contraindications and take these drugs for a short course, discontinuing them immediately after the disappearance of painful symptoms.

        Modern pharmacology has anti-inflammatory drugs of the so-called “selective action”, combining high efficiency and safety in use. Drugs such as Celecoxib (Celebrex), Rofecoxib and Etoricoxib have been successfully used to treat osteoarthritis.

        In recent years, the group of coxibs has been replenished with a new drug - Lumiracoxib, the active substance of which selectively disrupts the synthesis of prostaglandins. Just like other drugs in this group, the new generation drug is able to suppress prostaglandins involved in the inflammatory process. At the same time, there is no effect on the synthesis of prostaglandins, which regulate renal blood flow and maintain the integrity of the gastrointestinal mucosa.

        Celecoxib is a new generation drug that is most harmless to the stomach and intestines

        Chondroprotectors are used only at stages 1-2 of arthrosis to restore the structure of damaged cartilage through additional nutrition. The tablets contain chondroitin sulfate and glucosamine - substances that improve the formation of synovial fluid and its quality.

        Chondroprotective agents not only help eliminate painful symptoms, but also treat – this is their main purpose. While noting the undoubted benefits of these drugs, one cannot ignore the fact that the effect can only be achieved with long-term use of drugs from this group.

        A noticeable improvement in the condition occurs no earlier than six months after the start of therapy. Usually, several courses are prescribed to slow down the development of the pathological process and achieve stable remission.

        It is necessary to especially note the safety of use and the limited list of contraindications of chondroprotective drugs, which allows them to be prescribed to almost all patients. The most important condition for successful treatment is the systematic intake of adequate doses into the body: for Glucosamine this is 1000-1500 mg per day, for Chondroitin Sulfate - 800-1000 mg.

        Artra contains the same amount of active ingredients - Chondroitin and Glucosamine, it is recommended to take the tablets twice a day at first, after three weeks of use the daily dose is halved

        In the medical community, opinions regarding the separate or joint use of Glucosamine and Chondroitin Sulfate are divided. Some doctors are convinced of the benefits of combination drugs, while others consider monotherapy more effective. Both provide compelling arguments in defense of their views.

        How to understand this issue? There cannot be a clear answer here, however, in patients taking only Glucosamine, side effects from the gastrointestinal tract occur much more often. Doctors draw up a treatment regimen individually and prescribe monotherapy in case of intolerance to Chondroitin or Glucosamine.

        Structum is prescribed as an additional source of Chondroitin, the production of which is significantly reduced in osteoarthritis

        The joints do not have an independent blood supply, and all nutrients are provided by synovial fluid. It is from this that cartilage tissue takes the elements necessary for normal functioning.

        However, this happens only during joint movements: when the leg is bent, the fluid leaves the cartilage into the articular cavity, and when it extends, it returns to the cartilage, delivering nutrition to it. “Provision” for articular cartilage enters the synovial fluid from nearby blood vessels: when the periarticular muscle structures contract, the blood flow increases and more nutritional components enter the cartilage. Considering the features of this mechanism, recovery from arthrosis is unthinkable without therapeutic exercises.

        The action of Glucosamine is as follows:

      • the main cells of cartilage tissue – chondrocytes – are activated;
      • the production of Chondroitin Sulfate and Hyaluronic acid increases;
      • the activity of enzymes that threaten the integrity of cartilage is sharply reduced;
      • the negative impact of drugs from the group of NSAIDs and corticosteroids is minimized.
      • Chondroitin Sulfate complements the therapeutic effect of Glucosamine, acting in several directions:

      • is directly involved in the formation of Hyaluronic acid;
      • helps synthesize synovial fluid in the required volume;
      • has a pronounced anti-inflammatory effect;
      • prevents damage to cartilage by various enzymes.
      • Forms and types of chondroprotectors

        Hodndroprotectors are available in several forms - tablets, injections and ointments. Parenteral administration (bypassing the gastrointestinal tract) is required when it is necessary to quickly relieve inflammation or in the case of diseases of the digestive organs, especially the liver. The bioavailability of the drugs is the highest. Topical products are only effective as a complementary method.

        Chondroprotectors may contain Glucosamine or Chondroitin Sulfate, as well as their combinations. Products with an anti-inflammatory component are also produced, which can be prescribed if there are signs of inflammation - swelling, redness and severe pain.

        Currently, the best known drugs are Artra, Structum, Teraflex, Chondroitin Akos. All of them are available in tablets or capsules and are intended for oral use. For injections, Dona, Chondrolon and Elbona are most often prescribed.

        The intra-articular method of drug administration is used for severe pain that even powerful analgesics cannot cope with.

        Artra is a combination drug that contains Chondroitin, Glucosamine, Sodium Hyaluronate and Methylsulfonylmethane. The latter component has an anti-inflammatory effect and improves the absorption capacity of cartilage tissue.

        Sodium hyaluronate is produced by the body's own cells, but when the joint is damaged, its amount decreases. This element is necessary to make up for the deficiency.

        Structum is a single preparation containing Chondroitin of high sulfate, which is necessary to retain the maximum permissible volume of synovial fluid in cartilage tissue. Due to the high sulfate content, the firmness and elasticity of cartilage increases.

        Moreover, chondroitin in Structum has qualities close to natural and low molecular weight, which ensures rapid penetration of the drug through the membrane of the joint capsule. When taking the drug, the thickness of the cartilage is maintained and the shock-absorbing capacity of the knee joint increases. Among the analogues of Structum we can note Kartilag, Artrin, Chondrolon, Sigan, Hondrex, etc.

        How and with what to treat knee arthrosis is decided by the doctor, depending on the condition and individual characteristics of the patient. Chondroprotective agents are taken daily, the duration of one course is at least three months. The course is repeated several times at intervals of approximately six months for 2 or 3 years.

        It should be borne in mind that there are dietary supplements on sale that also contain Glucosamine and Chondroitin Sulfate. They are not full-fledged medicines because they have not undergone clinical trials. As an example, we can cite such dietary supplements as Chondro, Stopartrit Forte, Sustanorm Life formula.

        Treatment of synovitis that has developed against the background of gonarthrosis begins with taking a puncture to remove accumulated fluid

        Intra-articular injections

        Injections into the joint cavity are very effective and are carried out mainly in emergency situations. The indication for intra-articular administration of drugs is synovitis that occurs against the background of gonarthrosis and causes swelling of the joint due to the accumulation of fluid. This phenomenon significantly complicates or makes it impossible to perform therapeutic exercises, massage and physiotherapeutic procedures.

        In order to stop the inflammatory reaction, injections with hormonal drugs are prescribed - Kenalog, Diprospan, Hydrocortisone, Flosterone. The main advantage of this tactic is the rapid relief of pain and signs of inflammation. Since the effect of glucocorticosteroids is limited only to reducing the manifestations of arthrosis, most often only one injection is performed.

        If a repeated injection into the same joint is necessary, it is done no earlier than two weeks later. This approach is justified by the fact that corticosteroids have a prolonged effect, and the effect appears only after 12-14 days. The maximum number of procedures should not exceed 5, otherwise there is a high risk of developing unwanted effects.

        Hyalurome is a modern synovial fluid prosthesis; after its introduction, a significant reduction in pain is observed. The drug is successfully used even in advanced forms of arthrosis

        Intra-articular injections are prescribed with caution to patients with systemic diseases such as diabetes mellitus, hypertension, gastric ulcers, renal failure, and tuberculosis. Glucocorticosteroid drugs affect the entire body and can worsen the course of these pathologies.

        Hyaluronic acid preparations, which are also called “liquid prosthesis” or “implants,” can also be delivered into the cavity of the knee joint through direct injections. Such procedures have become firmly established in medical practice, and have been carried out quite successfully for about 15 years.

        Sodium hyaluronate acts similarly to natural joint lubrication, protecting bone surfaces from excessive friction. This slows down the destructive process in the cartilage, increasing its elasticity and flexibility.

        Thanks to additional infusions of Hyaluronate, cartilage tissue is restored and moisturized faster, mechanical stress is reduced, resulting in increased mobility and reduced pain in the knee.

        Side effects with intra-articular injection of Hyaluronic acid almost never occur. The treatment course consists of 3-4 injections with a break of one or two weeks. If necessary, the course is repeated again after 6-12 months.

        The only drawback of preparations based on Hyaluron is the rather high cost: the price of one injection ranges from 3,000 rubles. However, it should be recognized that expensive treatment is completely justified. According to doctors, many patients were literally able to “get back on their feet” precisely thanks to the additional hydration of the cartilage.

        Hydrocortisone in ampoules is intended for intra- and periarticular administration, the therapeutic effect occurs within 6-24 hours and lasts for a week or more

        Before the appearance of drugs containing Hyaluronic acid on the pharmaceutical market, prosthetic operations were performed much more often. Now the situation has changed, and it has become possible not only to be cured without surgery, but also to save money, since endoprosthetics is much more expensive than several injections.

        It is important to know that medications based on Hyaluronic acid are quickly destroyed after administration, so their use in acute inflammatory processes will be absolutely useless. The same applies to synovitis, in which a large amount of accumulated fluid is observed.

        To achieve the desired effect, you first need to stop the inflammation and achieve the resorption of excess fluid. For this purpose, either non-steroidal anti-inflammatory drugs or injections with corticosteroids are prescribed. Only then is a treatment course with Hyaluronate carried out.

        A pathology such as arthrosis of the knee joint can be successfully treated in the early stages. The possibilities of modern medicine are quite wide, but not limitless. Therefore, if symptoms such as pain and stiffness in the joints appear, it is recommended to consult a doctor and undergo a diagnosis. Timely and correct treatment will protect you from many complications and ensure high physical activity for many years. Be healthy!

        Choosing effective antibiotics for rheumatoid arthritis

        Arthritis is a collective term that characterizes joint damage of various etiologies. The disease is accompanied by pain and limited joint mobility.

        The causes of the inflammatory process can be:

      • immunogenetic disorders (rheumatoid arthritis);
      • intestinal and urogenital infection (reactive joint damage)
      • other diseases (lupus, gout, psoriatic arthritis);
      • injection of steroids into the joint cavity;
      • septic processes in the body.
      • In the vast majority of cases, inflammation is aseptic in nature.

        Purulent arthritis develops as a result of acute post-traumatic bursitis, accompanied by necrosis and melting of the walls of the joint capsule, with a breakthrough of its contents into the cavity of the adjacent joint.

        Differential diagnosis of joint damage

        Joint damage is bilateral. Characterized by morning stiffness in movements, the presence of rheumatoid nodules and extra-articular manifestations (vasculitis, neuropathies, pleurisy, acquired heart defects).

        Causes: chlamydia, yersinia, shigella, salmonella.

        Arthritis is asymmetrical, predominantly affecting the lower extremities, and is often combined with urethritis, cervicitis and conjunctivitis.

        Antibiotics for joint inflammation

        Drugs are selected taking into account the trigger infection that caused joint damage.

        The most justified prescription of tetracycline drugs will be. They have high activity against chlamydial and enterococcal flora and are well distributed in bone tissue.

        Tetracycline antibiotics in the treatment of rheumatoid arthritis are not etiotropic therapy. However, the use of minocycline and doxycycline (200 mg twice a day) can reduce the activity of enzymes that damage cartilage tissue, slow down degenerative processes in the joint, reduce swelling and reduce pain.

        With long-term use:

      • have a pronounced hepatotoxic effect, with a risk of developing fatty liver;
      • disrupt protein metabolism, contraindicated in patients with renal failure, lead to azotemia;
      • may provoke an increase in intracranial pressure;
      • Not recommended for use in children:

        1. disrupt bone formation;
        2. slow down linear bone growth;
        3. damage tooth enamel.

        Prohibited for use by pregnant and lactating women, as they can accumulate in the fetal skeleton and cause congenital deformities.

        It is important to remember that antibiotics for arthritis of rheumatoid etiology do not replace therapy with non-steroidal anti-inflammatory drugs, glucocorticosteroids, immunosuppressants and cytostatics.

        However, the effect of taking Sulfasalazine is practically not inferior to the effect of cytostatics, which allows the use of this drug in the basic therapy of rheumatoid arthritis, especially in the presence of contraindications to the use of Methotrexate.

      • pronounced antimicrobial activity;
      • anti-inflammatory effect.
      • It is well distributed in the body, penetrates tissue barriers, accumulates in connective tissue and synovial (joint) fluid.

        Features of use and side effects

        When carrying out therapy with sulfonamides, it is recommended to avoid ultraviolet radiation. It is also necessary to ensure sufficient drinking regime (at least two liters of water per day).

        These antibiotics for bones and joints are not used in pregnant women, due to their teratogenic effect on the fetus. Prohibited for use during lactation. Penetrates into breast milk, causing kernicterus and hemolytic anemia of newborns.

        Sulfonamides are not combined with estrogen-containing contraceptives and can cause uterine bleeding.

        Do not use in the presence of renal or liver failure in patients with folic acid deficiency and megaloblastic anemia.

        With long-term use, they inhibit bone marrow function (agranulocytosis) and can lead to exfoliative dermatitis, infertility and reversible oligospermia.

        Sulfasalazine application regimens

        The dose recommended for long-term therapy is 40 mg/kg (2 g per day, 1 g twice a day) starting from the fourth week of treatment.

        If there are complaints of a sore throat, the appearance of ulcers on the oral mucosa, severe bleeding, weakness and fever, therapy is stopped immediately.

        Antibiotics for arthritis of the knee joint of infectious etiology

        Third and fourth generation cephalosporins, aminoglycosides, sulfonamides, macrolides and penicillins are used.

        The third generation is consumed orally:

        In case of severe inflammatory process, Cefepime (4th generation) is prescribed parenterally.

        These antibiotics are effective for arthritis and arthrosis of staphylo-, strepto- and gonococcal etiology.

        For the treatment of arthritis of chlamydial etiology, the use of macrolides in daily dosages is effective. Antibiotics for arthritis in tablets:

        With prolonged use of Erythromycin, jaundice may occur as a result of the development of cholestatic hepatitis. Characteristic appearance: abdominal pain, yellowness of the skin and mucous membranes, severe itching, increased liver transaminases in a biochemical blood test.

        Rarely, the administration of high doses of Clarithromycin in patients with renal failure leads to reversible hearing impairment.

        Roxithromycin is contraindicated during pregnancy. It is permissible, with caution, to use Clarithromycin and Azithromycin (strictly under the supervision of a specialist).

        The use of Erythromycin and Josamycin is allowed.

        Antibiotics for arthrosis of the knee joint of post-traumatic etiology

        For destructive joint damage associated with purulent bursitis, fluoroquinolones are used.

        Surgical treatment of purulent arthritis

        Treatment of purulent inflammation of the joints is carried out in a surgical hospital.

        Surgical intervention, as a rule, is of an emergency nature, due to the patient’s delay in seeking medical help and prolonged self-medication.

        Surgery is performed under general anesthesia.

        The scope of preoperative preparation depends on the patient’s condition, the level of hemodynamics and the severity of symptoms of general intoxication.

        After puncture of the affected joint, its cavity is drained and washed with solutions of antibacterial drugs.

        In case of massive purulent infiltration of soft tissues, areas of necrosis are excised.

        In cases of osteomyelitis, purulent-necrotic destruction and bone sequestration, surgical intervention involves radical resection of the destroyed joint.

        Indications for arthrotomy are rapid deterioration of the patient's condition and lack of improvement after the puncture.

        Subsequent antibiotic therapy is carried out empirically, taking into account the suspected causative agents of purulent inflammation. Upon receipt of culture data (aspirated pus), it is possible to prescribe pathogenetic, highly targeted therapy.

        An integrated approach to the treatment of rheumatoid arthritis

        Treatment is prescribed only by a rheumatologist!

        To reduce pain and swelling, non-steroidal anti-inflammatory drugs (hereinafter NSAIDs) are used. It is preferable to begin treatment no later than three months from diagnosis.

        Use: diclofenac, ibuprofen, ketoprofen.

        In severe cases, meloxicam is prescribed.

        It is important to remember that NSAIDs do not affect the progression of destructive processes in the joints.

        Glucocorticosteroids

        The effect of glucocorticosteroid therapy is higher, however, it has a greater number of complications and side effects. The use of hormones slows down destruction in the joints in mild arthritis.

        Prescribed: methylprednisolone, dexamethasone, prednisolone.

        Visual video about arthritis:

        The main thing in the treatment of rheumatic joint damage is the selection of cytostatic therapy. These drugs slow down the progression of joint destruction, and in mild cases they can stop the destruction process.

        The most effective use of Methotrexate, Actemra, Rituximab, Arava.

        Infectious disease doctor A. L. Chernenko

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