The Institute of Rheumatology is one of the few metropolitan medical institutions that are seriously involved in the study of rheumatic diseases. Ultra-modern treatment methods make it possible to get rid of these diseases, and the patient’s age does not play a role.
The Research Institute of Rheumatology was founded in 1958, then it was called the State Research Institute of Rheumatology under the Ministry of Health of the RSFSR. This institution owes its discovery to one of the greatest scientists of that time - Academician A.I. Nesterov. It was he who made a huge amount of effort and was able to convince the local authorities that Moscow simply could not survive without such an institution.
The institute made a huge leap in development in the early 1970s, when Professor V. A. Nasonova became its director. Valentina Aleksandrovna managed in just a few years to turn the institute into a major center on a federal scale, which soon acquired international significance. Today the institute bears the name of V. A. Nasonova, who had a huge influence on the development of the institution.
The Institute of Rheumatology (Moscow) conducts active scientific activities in several areas at once. First of all, we are talking about the study of rheumatic diseases, their pathogenesis and etiological factors. For modern doctors, it is very important to correctly decipher the structure of existing autoantigens, which often cause the appearance of these diseases. Recently, molecular genetic diagnostics have been actively developing here, DNA microchips are being created for the purpose of further testing and implementation into regular practice.
Great attention is paid here to creating systems that can be used to monitor arthritis, one of the most common diseases among Russians. The institute is intensively studying risk factors associated with disorders of the cardiovascular system and capable of causing death. New examination and prevention programs are annually introduced by the Institute’s scientists, first into Russian and then into world practice.
Almost all leading doctors at the Institute of Rheumatology, located on Kashirskoye Shosse in Moscow, have scientific degrees. As of 2016, more than 35 doctors of science work here, and almost 80 doctors have defended their PhD degrees. About 25 specialists are still preparing to defend their scientific works, having enormous practical experience. The training of scientific personnel is taken very seriously here; no more than 20 people are accepted into graduate school and residency each year; the number of places in doctoral studies is even smaller; only the most worthy specialists are admitted there.
Most of the scientific work carried out at the institute is funded by the Russian Academy of Medical Sciences, and the association actively publishes the work of the institution's teachers and students. Every year, university representatives defend up to 20 new medical technologies; in addition, they constantly send information about their inventions to patent offices and defend their own developments.
The Moscow Research Institute of Rheumatology constantly holds congresses of rheumatologists, which attract specialists from all over the country. Numerous press conferences, meetings, symposiums, scientific readings, mini-schools - all this is aimed at significantly reducing the morbidity threshold for Russians and protecting them from health problems.
As of 2016, there are two departments within the institute that are engaged in research, trying to make scientific discoveries in the most important areas of rheumatology. Thanks to the work of the department’s specialists, modern treatment standards were developed and adopted by the Ministry of Health of the Russian Federation.
The Institute of Rheumatology of the Russian Academy of Medical Sciences (Moscow) is part of the Association of Rheumatologists of Russia, a public organization that aims to unite specialists from different parts of the country and give them the opportunity to exchange experiences. The association has more than 40 branches in the regions and continues to actively develop. The most important goal of this community is the joint creation of the most relevant treatment methods, their testing in the regions and further analysis.
In addition, the ARR also performs a humanitarian function. First of all, we are talking about organizing communities of those patients who have been suffering from rheumatic diseases for a long time. Patients can receive advice from specialists, as well as exchange experiences with fellow sufferers. Rheumatologists monitor the well-being of their patients and are actively working to create new treatment methods, partially testing them on their patients with the consent of the latter.
The Institute of Rheumatology on Kashirka is open on weekdays, from 9 a.m. to 5 p.m., during which time patients with rheumatic diseases can turn there for help. First, you need to make an appointment for an outpatient appointment; this can be done by calling on weekdays, from 9 a.m. to 4 p.m., by calling 8 (495) 662-50-40. You will be advised in detail on existing diseases, and will also be offered to visit the most suitable specialist. Please note: appointments are by appointment only; patients with emergency attacks are best advised to go to other medical institutions.
The Institute of Rheumatology of the Russian Academy of Medical Sciences offers two types of treatment: outpatient and inpatient. In the first case, the patient, when contacting the institution, will be able to receive scientific advice, as well as paid medical care. The hospital is more convenient because doctors have the opportunity to conduct a full examination, identify the presence/absence of diseases, and then, if necessary, treat them. The institute is also actively involved in the implementation of government tenders and provides specialized inpatient care under compulsory medical insurance policies.
Patients who have once visited the Research Institute of Rheumatology speak quite positively about this institution. Doctors, in their opinion, approach their duties as responsibly as possible and try to relieve the pain experienced by patients as soon as possible. Also among the advantages of the institute is its convenient location.
Many patients complain that during surgical interventions a large number of trainees may be present in the operating room, which causes psychological discomfort. In addition, patients are dissatisfied with the fact that they cannot go to the institute with acute pain, or call the institution’s specialists to their home in the event of a crisis situation.
If your attending physician, while carrying out your current treatment, notices that you have pathologies that require inpatient monitoring, he has the right to refer you to the Nasonova Institute of Rheumatology. You receive a referral from your specialist, and then contact the institute administration with it.
Each patient referral is reviewed by a scientific commission, which includes institute staff, as well as consultants who monitor compliance with existing indications for hospitalization. After making a decision, the commission notifies the patient by mail or by telephone and offers him the most convenient time for treatment, which should be carried out as soon as possible.
The Institute of Rheumatology on Kashirka is also actively involved in educating related specialists. From time to time, the local training center conducts special courses on common medical problems faced by specialists in various fields. In particular, we are talking about courses in modern rheumatic orthopedics, which are in demand among surgeons and traumatologists.
Upon completion of any training course, the Institute of Rheumatology issues its students a corresponding certificate, which can later be used to confirm their qualifications or for further training. The center at the institute offers its students to learn from the experience of Russian and foreign scientists, get acquainted with the most current medicinal drugs, etc.
The Institute of Rheumatology was created to help all patients with rheumatic diseases, a function it has successfully performed for more than 50 years. The university actively cooperates with colleagues from Italy, Portugal, France, Spain, USA, Greece, Hungary and many other countries from different parts of the world. Due to this, it is possible to create a unified media space in which it is possible to create new methods for the treatment of rheumatic diseases.
Federal State Budgetary Scientific Institution
named after V.A. Nasonova
Moscow, Kashirskoe highway, 34A
Mon. — Fri. from 9:00 to 20:00
Sat. from 9:00 to 16:00
Rheumatoid arthritis (RA) is an immunoinflammatory rheumatic disease of unknown etiology. It is characterized not only by the development of chronic erosive arthritis of peripheral joints, but also by systemic damage to internal organs, such as the heart, kidneys, lungs, blood vessels, etc. Delayed diagnosis of RA leads to early disability and a reduction in the life expectancy of patients. RA is a common and one of the most severe human immunoinflammatory diseases. The ratio among sick women and men is 3:1.
Early symptoms of the disease that will help you suspect the development of RA:
Morning stiffness in the joints for more than 30-60 minutes.
Joint pain, joint tenderness on palpation and movement.
Swelling of soft tissues in the joints and tendons.
Inflammation of the joints is manifested by pain, swelling and limitation of movement in them. These symptoms are especially pronounced in the morning, after sleep. Many patients complain of “morning stiffness” in the joints. The “calling card” of rheumatoid arthritis is considered to be damage to the joints of the hands and feet, although the disease can begin with the development of inflammation in almost any joint. Pain when shaking hands (positive transverse compression test of the hand), the inability to completely clench the hand into a fist are typical manifestations of inflammation in the joints of the hands and serve as an alarming signal indicating the need to contact a rheumatologist in the near future.
To make a correct and timely diagnosis, assess the severity of the disease and its prognosis (inflammatory activity, function and destruction of joints, immunological indicators) is the task of a rheumatologist. At our institute you will be able to conduct a detailed examination using immunological and instrumental methods aimed at early diagnosis of rheumatoid arthritis: x-ray examination of the joints of the hands and feet, magnetic resonance imaging of the joints (which allows you to identify changes not yet visible on x-rays), ultrasound examination of the joints, immunological blood test (RF and ACCP - which are the main diagnostic laboratory biomarkers of RA), determination of ESR and CRP - biomarkers of the inflammatory process.
If a diagnosis is made in time and modern treatment is prescribed, the disease can be controlled. People with such a diagnosis can live a completely normal life, work, have a family and children.
It is very important to timely identify risk factors for an unfavorable prognosis of the course of RA:
The patient has ACCP and RF.
High inflammatory activity (high ESR and CRP, number of swollen and painful joints).
Early structural changes (detection of erosions during X-ray examination of joints in the first 6 months from the onset of the disease).
The presence of severe concomitant pathology.
Proven principles for successful treatment of RA (“Treat to Goal”) are:
Currently, a rheumatologist has a wide arsenal of highly effective and relatively safe medications used to treat RA. Therapy with synthetic basic antirheumatic drugs (methotrexate, leflunomide, sulfasalazine) should begin as soon as a diagnosis of RA is made by a rheumatologist.
The main goals of RA treatment are:
relief of disease symptoms, achievement of clinical and laboratory remission or at least low disease activity;
inhibition of the progression of structural changes in joints and corresponding functional disorders;
improving the quality of life of patients, maintaining their ability to work;
prevention of cardiovascular diseases;
prevention of the development of AA amyloidosis, which leads to chronic renal failure.
If DMARDs are insufficiently effective (maintaining moderate/high disease activity), or DMVT is poorly tolerated, the use of genetically engineered biological drugs (GEBPs) is recommended. Our institution operates a state system for the provision of high-tech medical care (HTMC), which allows you to receive treatment with the latest drugs.
The Early Arthritis Laboratory specializes in early diagnosis and treatment of patients with inflammatory diseases of peripheral joints, primarily rheumatoid arthritis.
Arthritis is a fairly common condition that affects many people. Accordingly, arthritis treatment should be carried out in every clinic. But the quality of services is not always good, and an experienced doctor is sometimes quite difficult to find.
But in our medical center “Institute of Clinical Medicine” you can get consultations with real specialists.
Treatment of arthritis in Kyiv is carried out using the “Turbomag” general magnetic therapy device. This treatment involves applying magnetic fields to the human body. Thanks to this, high efficiency in treatment is achieved. With this treatment, the exchange of various processes in the human body is normalized, and microcirculation in the affected joints is improved.
By the way, you do not need to take any additional actions or any measures before going through this procedure. You will lie on the couch in complete peace and will even be able to move easily. Treatment of joint diseases should be carried out in such a way that a person does not feel discomfort.
Arthritis can take many forms. Thus, we can talk about the types of arthritis. They differ in the nature of the lesion. So , these include the following types:
All of these types of arthritis have many causes. This may include joint damage, repeated trauma, metabolic disorders, physical overexertion, cooling, vitamin deficiency, poor occupational and household hygiene, and infections.
Treatment of joints involves the use of a number of measures that significantly reduce the symptoms of the disease. They are also aimed at restoring proper metabolism in damaged cartilage and maximizing the preservation of joint functions. In addition to using basic measures to cure joint diseases, reflexology, manual therapy, and physical therapy are also used.
Treatment of polyarthritis in Kyiv is carried out using special equipment. The course of treatment consists of 10-15 sessions. Typically one session lasts about 1 hour. If necessary, it may be recommended to take the course again. After 3-4 sessions, the following positive results in the treatment of arthritis appear:
Accordingly, polyarthritis treatment is carried out professionally and efficiently. You can be confident in the experience of our specialists and completely surrender to their hands. If you have any of the following symptoms, you will need help from a doctor:
If you contact our clinic in time, you will not only be able to prevent the development of the disease, but will also be able to receive important recommendations on how to prevent the recurrence of the disease. Take care of your health, because you have one for life.
Rheumatoid arthritis is a chronic autoimmune systemic inflammatory disease of connective tissue with predominant damage to the joints of the type of erosive-destructive progressive polyarthritis. The disease affects 0.5-1% of the population. Around the world, about 58 million people suffer from rheumatoid arthritis.
The exact cause of rheumatoid arthritis is unknown. The pathogenesis of rheumatoid arthritis is based on genetically determined autoimmune processes, the occurrence of which is facilitated by a deficiency of the T-suppressor function of lymphocytes. An unknown etiological factor causes the development of an immune response. Damage to the joint begins with inflammation of the synovial membrane (synovitis), which then acquires a proliferative nature (pannus) with damage to cartilage and bones. Plasma cells of the synovium produce altered aggregated IgG. In turn, it is recognized by the immune system as a foreign antigen, and plasma cells of the synovium, lymph nodes, and spleen begin to produce antibodies to it - rheumatoid factors (RF). The most important is the IgM class RF, which is found in 70-80% of patients with rheumatoid arthritis.
As a result of the autoimmune inflammatory process, pannus is formed - granulation tissue originating from the inflamed synovial membrane, consisting of actively proliferating fibroblasts, lymphocytes, macrophages and rich in blood vessels. The pannus grows rapidly, penetrates from the synovial tissue into the cartilage and destroys it through the action of enzymes induced by the production of cytokines within the pannus itself. Gradually, the intra-articular cartilage disappears, it is replaced by granulation tissue and ankylosis develops. Chronic inflammation of the periarticular tissues, joint capsules, ligaments, tendons leads to joint deformities, subluxations, and contractures. Currently, there is a point of view that autoimmune processes play a leading role in the early stages of rheumatoid arthritis, and in later stages non-immune mechanisms (i.e. the ability of the pannus to grow, invade and destroy articular cartilage) are more important.
Articular syndrome is the leading clinical manifestation of rheumatoid arthritis. Typical for rheumatoid arthritis is bilateral symmetrical damage to the joints. The onset of the disease is often associated with unfavorable weather conditions (spring, autumn), periods of physiological restructuring of the body (puberty, postpartum, menopause). The development of rheumatoid arthritis can be triggered by an infection, cold, injury, or a stressful situation.
The most common lesions of rheumatoid arthritis are the joints of the hands, feet, wrists, knees, and elbows. Rarely the shoulder, hip and spinal joints are affected. Damage to the joints in rheumatoid arthritis, as a rule, is symmetrical in nature, accompanied by a feeling of morning stiffness, a sharp limitation of mobility in the joints, which significantly limits the ability to self-care (difficulty dressing, washing, combing one's hair, shaving, etc.) and ability to work. The more active the inflammatory process in the joints, the longer the duration of morning stiffness.
Kidney damage in the form of glomerulonephritis or amyloidosis is the most severe visceral manifestation of rheumatoid arthritis. Rheumatoid glomerulonephritis usually develops with high activity of the process and is most often characterized by isolated urinary syndrome (proteinuria, microhematuria), which disappears after the exacerbation of rheumatoid arthritis has stopped. Less common is diffuse glomerulonephritis with persistent proteinuria, microhematuria, increased blood pressure, edema, and impaired renal function. In some cases, glomerulonephritis may result in nephrosclerosis.
Kidney amyloidosis usually develops with a long course of rheumatoid arthritis (more than 7-10 years) and high activity of the process. Main manifestations: persistent proteinuria (1-3 g/l), cylindruria, edema, arterial hypertension, gradual impairment of concentration (isohyposthenuria in the Zimnitsky test) and nitrogen excretory functions of the kidneys. With the development of chronic renal failure, anemia appears. Kidney amyloidosis may be accompanied by the development of nephrotic syndrome, which is characterized by high proteinuria (protein concentration in the urine 6-8 g/l), hypoproteinemia, hypocholesterolemia, severe edema, rapidly developing renal failure, and anemia.
Degrees of activity of rheumatoid arthritis:
I degree (minimal activity). Minor pain in the joints, short-term stiffness in the morning (up to 30 minutes), minor exudative phenomena in the joints, the temperature of the skin over the joints is normal or slightly elevated. ESR is increased to 20 mm/h, the number of leukocytes in the blood is normal, the level of alpha-2-globulins is increased to 12%, C-reactive protein (CRP)+, fibrinogen and sialic acids are slightly increased.
II degree (average activity). Pain in the joints not only during movement, but also at rest, stiffness continues until noon, severe painful limitation of mobility in the joints, moderate stable exudative phenomena. Hyperthermia of the skin over the joints is moderate. Damage to internal organs is not clearly expressed, body temperature is low-grade. ESR is increased - from 25 to 40 mm/h, the number of leukocytes in the blood is 8-10?109/l, the content of alpha-2-globulins is increased to 15%. CRP ++, significantly increased levels of sialic acids and fibrinogen.
III degree (high activity). Severe pain at rest, severe exudative phenomena in the joints (significant swelling, hyperemia and increased skin temperature), stiffness throughout the day, severe limitation of mobility.
Signs of an active inflammatory process in the internal organs (pleurisy, pericarditis, carditis, nephritis, etc.): high body temperature. ESR exceeds 40 mm/h, the number of leukocytes in the blood is 15-20?109/l, agglobulins are more than 15%, PSA+++, the content of fibrinogen and sialic acids is sharply increased.
Functional disorders (FD) of the musculoskeletal system:
FN I - slight restriction of movements in the joints, a feeling of slight stiffness in the morning; professional suitability is usually preserved, but somewhat limited (hard work is contraindicated).
FN II – restriction of movements in joints, persistent contractures, self-care is difficult, professional fitness is usually lost.
FN III – stiffness or complete absence of movement in the joints, the ability to self-care is lost, the patient needs constant care.
Treatment of RA is symptomatic, aimed at reducing the severity of the inflammatory process in the joints: glucocorticosteroids, non-steroidal anti-inflammatory drugs, local anesthetic and anti-inflammatory therapy, physiotherapy.
The use of stem cells to treat rheumatoid arthritis has been tested in at least 15 clinical trials. Treatment approaches vary. One of the directions is the isolation of mesenchymal stem cells from the patient’s bone marrow, their transformation into cartilage cells (chondrocytes) and injection directly into the affected joint. Another direction involves the systemic introduction of hematopoietic and/or mesenchymal cells into the bloodstream to reduce the manifestations of autoimmune aggression.
The Institute of Cell Therapy has developed a method for complex treatment of rheumatoid arthritis, based on simultaneous transplantation of hematopoietic and mesenchymal stem cells. It is important that in this case three goals are achieved: restoration of damaged joint tissues by stimulating the patient’s own regenerative resources under the influence of growth factors produced by cells; replenishment of stem reserves for the regeneration of synovial, cartilage and bone tissue due to mesenchymal cells; elimination of the autoimmune component of the disease and blocking further progression of the disease due to the immunosuppressive and tolerogenic effects of mesenchymal and hematopoietic stem cells. The method has significant limitations: it is permissible to use such a transplantation only if the degree of activity of rheumatoid arthritis is I-II and functional insufficiency of the joints is 0-I.
Clinical example. As an example, we present diagrams of changes in indicators of the clinical course of rheumatoid arthritis of participants in a clinical trial, which was conducted by the Coordination Center for Organ, Tissue and Cell Transplantation of the Ministry of Health of Ukraine on the basis of the Institute of Cell Therapy.
Control group (ST) – 29 patients, RA, activity I, functional joint failure I, polyarthritis, seropositive, slowly progressive course. Treatment: placvenil, delagil, methotrexat, movalis, diklofenal-sodium, indometacine, ibuprofen.
Main group (TEPC) – 21 patients, RA, activity I, functional joint failure I, polyarthritis, seropositive, slowly progressive course. Treatment: single hematopoietic stem cell transplantation. Dose: 0.4? 106/kg body weight. Phenotype: CD34+CD133+CD38-CD45RAlow CD71low CD7HLA-DRlow.
Clinic of Traumatology, Orthopedics and Joint Pathology of the First Moscow State Medical University named after. THEM. Sechenov Ministry of Health of Russia (Sechenov University) was organized in 2009. The clinic is a structural subdivision of the University's clinical center.
Today it is one of the largest scientific and educational bases not only in Moscow, but also in the country. Students, clinical interns and residents, and graduate students study here. The treatment process is carried out by specialists who train new personnel to work in healthcare.
The staff of the clinic allows us to solve the most complex problems. All medical personnel have qualification categories. Patients are received by leading specialists in Moscow: doctors and candidates of medical sciences, professors, associate professors, assistants with many years of experience in clinical and scientific work.
Today, the clinic is a dynamically developing organization that actively implements all the latest achievements of medical science into practice.
The structure of the clinic includes two departments of traumatology and orthopedics, designed for simultaneous stay of 70 inpatients. In addition to standard rooms, patients are provided with double, single and single hotel-type rooms with improved conditions. The capacity of the traumatology departments allows us to admit more than 2,000 patients annually. The wards, treatment rooms, medical and teaching staff are located in the same building, which eliminates the need to search among many buildings and floors.
One of the key specializations of the clinic is performing high-tech operations using innovative minimally invasive and endoscopic technologies. In recent years, the medical institution has significantly reduced the morbidity of surgical interventions, the number of complications and the period of postoperative rehabilitation. Close cooperation with the largest orthopedic centers in Western Europe, Israel and the USA allows us to quickly implement the latest world scientific achievements into practice. Thanks to these factors, a rapid return to work capacity and restoration of the patients’ previous quality of life are ensured.
Popular wisdom: If you have many diseases, it means your spine is sick
Imagine that your back no longer bothers you. Nothing hurts anywhere. Not in the neck, not in the lower back, not in the head. No pain in arms and legs. This is not a myth - this is reality. Our center specializes in the treatment of diseases of the musculoskeletal system. And you are guaranteed to feel the results after your first visit to us.
Back pain signals problems in the spine.
The spine is the axis of the human body. Its upper part is connected to the skull, the lower part to the pelvic bones. Inside it, there is a cavity - the spinal canal, in which the spinal cord is located. In a healthy spine, each spinal nerve functions
Pain and suffering are not very good companions in life. But they push us to certain actions.
One of them brought you to us - to the European Center for Vertebrology.
Our specialization is the treatment of diseases of the spine and large joints.
In any form and at any stage.
— osteochondrosis of the spine (including complicated by radicular syndrome);
— protrusion of intervertebral discs;
— herniated intervertebral discs;
- arthrosis and arthritis;
- plantar fasciitis (heel spur);
- flat feet and many other diseases of the musculoskeletal system.
Vertebrology studies diseases of the spine. This is a unique science that has the capabilities of orthopedics, neurology and neurosurgery. That is why vertebrologists have the invaluable knowledge that allows them to put seemingly hopeless patients back on their feet. A distinctive feature of our center is a comprehensive view of “breakdown” in the body. After all, it is impossible to separate the function of the spine from other organs and systems of the body. Therefore, we use in our practice both academic knowledge of European medicine and oriental restoration techniques.
By visiting our center, you will forget about queues, endless consultations with different doctors, and constant testing. You will stop wasting your money on medications that relieve symptoms but do not eliminate the causes.
A unique spinal correction technique has been developed for you . Doctors are specialists of the highest category with 20 years of experience behind them. No surgical intervention. Only the confident and caring hands of professionals in their field. You will receive all the experience and knowledge collected over the 15 years of the center’s existence. The center's specialists will monitor you throughout the course of treatment. Until your complete recovery.
Various rheumatic diseases can appear at different ages. But most often, of course, mature people are susceptible to such diseases. In this case, you need to visit an experienced rheumatologist to get a quality examination and appropriate treatment.
At our medical center “Institute of Clinical Medicine”, a rheumatologist is ready to provide you with various types of services.
If you have problems associated with rheumatic diseases, then you definitely need to visit a doctor to identify the causes of the disease, as well as prescribe the necessary treatment.
Rheumatology is the study, diagnosis and treatment of rheumatic diseases. This field covers the treatment of many diseases. It could be the following:
This area of medicine is quite closely related to other areas, since disorders of immune processes can be observed. The main thing is to seek help in a timely manner.
Rheumatic diseases most often occur in people in adulthood, but a child may also need the help of a specialist. Children's rheumatological diseases have their own characteristics and also require slightly different treatment.
Rheumatism can be cured. No matter how advanced the form of the disease, specialists from our medical center will take on even the most complex manifestations of rheumatic disease. Therefore, if you feel some symptoms indicating the presence of rheumatic diseases, you need to immediately undergo a high-quality diagnosis.
The main symptoms include the following: